Foxp1 controls mature B cell survival and the development of follicular and B-1 B cells

Foxp1 controls mature B cell survival and the development of follicular and B-1 B cells

The transcription factor Foxp1 is critical for early B cell development. Despite frequent deregulation of Foxp1 in B cell lymphoma, the physiological functions of Foxp1 in mature B cells remain unknown. Here, we used conditional gene targeting in the B cell lineage and report that Foxp1 disruption in developing and mature B cells results in reduced numbers and frequencies of follicular and B-1 ...

the investigation of the relationship between type a and type b personalities and quality of translation

چکیده ندارد.

Cell Generation Germinal Center B Cell Survival, and Plasma Murine T Follicular Helper Development, CD80 Expression on B Cells Regulates

Homeostatic Proliferation, Cell Survival, and The Role of IL-5 for Mature B-1 Cells in

c-Myb is critical for B cell development and maintenance of follicular B cells.

The c-Myb transcription factor is crucial during definitive hematopoiesis. However, the embryonic lethality of Myb traditional null mutations has precluded analysis of c-Myb function in lymphocytes. Using tissue-specific inactivation at the Myb locus, we demonstrate that loss of Myb causes a partial block during B cell development at the pro-B to pre-B cell transition, resulting in greatly decr...